Citation :

Rayhaan Ansh Malhotra, Sulagna Dutta, "Exploring Gene Therapy as a Cure for Age-Related Macular Degeneration," International Journal of Biotech Trends and Technology (IJBTT), vol. 15, no. 2, pp. 1-4, 2025. Crossref, https://doi.org/10.14445/22490183/IJBTT-V15I2P101

Abstract

Age-related Macular Degeneration (AMD) is a complex disorder and a major cause of blindness in elderly people across the globe. This condition originates at the retina but spreads to the inner layers of the eye. In AMD, the macular lining of the eye, which is primarily involved in vision, becomes damaged. Consequently, straight lines appearing wavy and distorted are observed as an early symptom of AMD. Multiple factors, including genetic history, lifestyle, and reactive oxygen stress cause the inception of AMD. Several advanced therapies are in clinical trials for the treatment of this life-changing disorder, but none of them promise a perfect cure. Gene Therapy aims to deliver the correct copy of the RPE65 gene (which is responsible for the condition) to the retina and help in the production of the proper RPE65 protein to maintain vision. An advantage of this method is its potential to reduce the number of continuous injections, unlike other therapies under trial.

Keywords

Age-related Macular Degeneration (AMD), RPE65 gene, Retina, Gene Therapy.

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